反应详情

Dissolving 3,4,5-trimethoxyl benzyl bromide (16.05 g, 61.47 mmol) in toluene (150 ml) in a 250 ml three-necked flask, adding triphenylphosphine (16.12 g, 61.47 mmol) and dissolving immediately. The reaction mixture was heated to reflux for 1 hour, white solid was separated, then cooling to room temperature, suction filtering, the filter cake was washed with toluene (30 ml). After vacuum drying, 3,4,5-trimethoxyl benzyl triphenylphosphine bromide (27.81 g of white powder solid) was isolated, yield: 86.44%.

1. dissolutiondissolving immediately
2. temperatureThe reaction mixture was heated
3. temperatureto reflux for 1 hour
4. customwhite solid was separated
5. filtrationsuction filtering
6. washthe filter cake was washed with toluene (30 ml)
7. customAfter vacuum drying