Hydrochloric Acid → HCID 67374716, compound

HRID 1867798Notes

Reaction equation

HRID 1867798 reaction equation
[CH3:1][NH:2][C:3]([C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:23][CH2:22][CH2:21][C@H:20]3[CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:18])=[CH:13][CH:12]=2)=[CH:7][CH:6]=1)=[O:4].[ClH:30]>ClCCl.CCOCC>[ClH:30].[CH3:1][NH:2][C:3]([C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][C:14]([C:17]([N:19]3[CH2:23][CH2:22][CH2:21][C@H:20]3[CH2:24][N:25]3[CH2:29][CH2:28][CH2:27][CH2:26]3)=[O:18])=[CH:13][CH:12]=2)=[CH:9][CH:10]=1)=[O:4]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 57980181HCID 57980181, compound

Product 1

HCID 67374716HCID 67374716, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 6344DichloromethaneSolvent

Procedure

Procedure AA: Dissolve 4′-(2-(S)-Pyrrolidin-ylmethyl-pyrrolidine-1-carbonyl)-biphenyl-4-carboxylic acid methylamide in minimal dichloromethane and add 1M hydrochloric acid in ether until the solution becomes cloudy. Add 1:1 ether/hexanes and concentrate in vacuo to yield the title compound. MS (m/e): 392.3 (M+1)

Workup

  1. concentrationconcentrate in vacuo

Sources & evidence

ORD record
ord-f3dc6e7caf4046c2a5c8cea56d0932c2
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

Loading…