4-Bromo-2-fluorobenzoic acid → HCID 57980062, compound

HRID 1867845Notes

Reaction equation

HRID 1867845 reaction equation
Br[C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=O)=[C:4]([F:11])[CH:3]=1.[CH2:12]([S:14]([C:17]1[CH:22]=[CH:21][C:20](B(O)O)=[CH:19][CH:18]=1)(=[O:16])=[O:15])[CH3:13].[CH3:26][C@@H:27]1[CH2:31][CH2:30][CH2:29][N:28]1[CH2:32][C@@H:33]1[CH2:37][CH2:36][CH2:35][NH:34]1>>[CH2:12]([S:14]([C:17]1[CH:22]=[CH:21][C:20]([C:2]2[CH:10]=[CH:9][C:5]([C:6]([N:34]3[CH2:35][CH2:36][CH2:37][C@H:33]3[CH2:32][N:28]3[CH2:29][CH2:30][CH2:31][C@H:27]3[CH3:26])=[O:8])=[C:4]([F:11])[CH:3]=2)=[CH:19][CH:18]=1)(=[O:16])=[O:15])[CH3:13]

Participants

4

Reactant 3

HCID 3026814-Bromo-2-fluorobenzoic acidHCID 27734204-(Ethylsulphonyl)benzeneboronic acidHCID 46911921(R)-2-methyl-1-((S)-pyrrolidin-2-ylmethyl)pyrrolidine

Product 1

HCID 57980062HCID 57980062, compound

Procedure

The title compound is prepared in a manner substantially analogous to Procedure A′, T′ and B′ starting from 4-bromo-2-fluoro-benzoic acid, 4-ethanesulfonylphenyl boronic acid and 2-(R)-Methyl-1-(2-(S)-pyrrolidinylmethyl)pyrrolidine. MS (M+H) 459.2

Sources & evidence

ORD record
ord-6c0d3118343a4b929441f6bff0f8d7fd
Source dataset
uspto-grants-2009_12
Patent number
US07632857B2

Reaction notes

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