反应详情

3-Fluoro-4-carboxy-phenylboronic acid (CAS 120153-08-4)(1.0 g, 5.4 mmol) and pinacol (0.645 g, 5.4 mmol) were stirred in Toluene/EtOH (1:1) (30 ml) with heating to give a thick white slurry. The mixture was concentrated under reduced pressure, toluene (30 ml) was added and the mixture was again concentrated under reduced pressure to a white solid. LCMS(-ve ion mode) showed a single peak trace with 265 (M−H RP). The material was dried under high vacuum overnight to give 1.42 g.

1. temperaturewith heating
2. customto give a thick white slurry
3. concentrationThe mixture was concentrated under reduced pressure, toluene (30 ml)
4. additionwas added
5. concentrationthe mixture was again concentrated under reduced pressure to a white solid
6. customThe material was dried under high vacuum overnight
7. customto give 1.42 g