HCID 11993208, compound → HCID 11993404, compound

HRID 1867883Notes

Reaction equation

[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)=[CH:10][C:11]2[N:12]([C:14]([C:17]34[CH2:23][C:20]([O:24]C)([CH2:21][CH2:22]3)[CH2:19][CH2:18]4)=[N:15][N:16]=2)[N:13]=1.ClC1C=CC=CC=1C1C(C2C=CC(Cl)=CC=2)=CC2N(C(C34CCC(O)(CC3)CC4)=NN=2)N=1>>[Cl:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[C:8]1[C:9]([C:26]2[CH:31]=[CH:30][C:29]([Cl:32])=[CH:28][CH:27]=2)=[CH:10][C:11]2[N:12]([C:14]([C:17]34[CH2:23][C:20]([OH:24])([CH2:21][CH2:22]3)[CH2:19][CH2:18]4)=[N:15][N:16]=2)[N:13]=1

Participants

Reactant 2

HCID 11993208HCID 11993208, compound

HCID 11993403HCID 11993403, compound

Product 1

HCID 11993404HCID 11993404, compoundYield 79.8%

Procedure

The title compound (36 mg, 79%) as a light yellow foam was prepared from 6-(2-chlorophenyl)-7-(4-chlorophenyl)-3-(4-methoxybicyclo[2.2.1]heptan-1-yl)-[1,2,4]triazolo[4,3-b]pyridazine (Example 17) (47 mg, 0.1 mmol) according to the procedures described for 4-(6-(2-chlorophenyl)-7-(4-chlorophenyl)-[1,2,4]triazolo[4,3-b]pyridazin-3-yl)bicyclo[2.2.2]octan-1-ol (Example 30). HPLC/MS (method A): retention time=3.60 min, (M+H)+=451.2.

Sources & evidence

ORD record: ord-616d53b13c7c47b498402990dba22a89
Source dataset: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07632837B2

Reaction notes

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