Bromine → 1-Bromo-2,4-difluorotoluene

HRID 1867916Notes

Reaction equation

HRID 1867916 reaction equation
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[CH3:9].[Br:10]Br>[Fe]>[Br:10][C:3]1([CH3:9])[CH:4]=[CH:5][C:6]([F:8])=[CH:7][CH:2]1[F:1]

Participants

4

Reactant 2

HCID 24408BromineHCID 679832,4-Difluoro-1-methylbenzene

Product 1

HCID 669699201-Bromo-2,4-difluorotoluene

Reagents, catalysts & solvents 1

HCID 23925IronCatalyst

Procedure

The title compound was prepared by a modification of a published procedure. 2,4-Difluorotoluene was treated with iron chip and bromine at 60° C. overnight under an argon atmosphere in quantitative yield.

Sources & evidence

ORD record
ord-f000b9c670c345e88afb9cfaa812774e
Source dataset
uspto-grants-2009_12
Patent number
US07632932B2

Reaction notes

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