Toluene → Quinoline

HRID 1867929Notes

Reaction equation

HRID 1867929 reaction equation
ClCCC(O[CH2:7][CH2:8][N:9]=C=O)=O.[C:12]1([CH3:18])[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>>[N:9]1[C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:18]=[CH:7][CH:8]=1

Participants

3

Reactant 2

HCID 1140TolueneHCID 15131407HCID 15131407, compound

Product 1

HCID 7047Quinoline

Procedure

A three-necked flask was charged with 250 ml of toluene, 60 g (0.34 mol) of (2-isocyanatoethyl) 3-chloropropionate obtained in Synthesis Example 2, and 63 g (0.49 mol) of quinoline (boiling point: 237.7° C.), followed by heating at 50° C. for 6 hours with stirring. No acryloyloxyethyl isocyanate was confirmed by gas chromatography analysis.

Sources & evidence

ORD record
ord-71d253ef34064a82a1da3c70ed8d4018
Source dataset
uspto-grants-2009_12
Patent number
US07632965B2

Reaction notes

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