Hydrochloric Acid → HCID 11706812, compound

Participants

Reaction Steps

2nd step: A solution of 103 mg of 4-({6-[4-(3-imidazol-1-ylpropylamino)-benzenesulfonyloxy]benzothiazol-2-ylcarbamoyl}methyl)piperidine-1-carboxylic acid tert-butyl ester, 2 ml of dioxane and 2 ml of 4N hydrochloric acid in dioxane is stirred for 3 hours at room temperature. The precipitate obtained is filtered off and washed with dioxane and ethyl ether to give 110 mg of 4-(2-isopropylaminoethylamino)benzenesulfonic acid 2-(2-piperid-4-ylacetylamino)benzothiazol-6-yl ester hydrochloride (white powder) in a yield of 88%.

Provenance & Evidence