Hydrochloric Acid → HCID 11706812, compound

HRID 1867967Notes

Reaction equation

HRID 1867967 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15](=[O:45])[NH:16][C:17]2[S:18][C:19]3[CH:25]=[C:24]([O:26][S:27]([C:30]4[CH:35]=[CH:34][C:33]([NH:36][CH2:37]CCN5C=CN=C5)=[CH:32][CH:31]=4)(=[O:29])=[O:28])[CH:23]=[CH:22][C:20]=3[N:21]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:46]>O1CCOCC1>[ClH:46].[NH:8]1[CH2:9][CH2:10][CH:11]([CH2:14][C:15]([NH:16][C:17]2[S:18][C:19]3[CH:25]=[C:24]([O:26][S:27]([C:30]4[CH:35]=[CH:34][C:33]([NH:36][CH2:37][CH2:17][NH:21][CH:20]([CH3:22])[CH3:19])=[CH:32][CH:31]=4)(=[O:29])=[O:28])[CH:23]=[CH:22][C:20]=3[N:21]=2)=[O:45])[CH2:12][CH2:13]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86612147HCID 86612147, compound

Product 1

HCID 11706812HCID 11706812, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

2nd step: A solution of 103 mg of 4-({6-[4-(3-imidazol-1-ylpropylamino)-benzenesulfonyloxy]benzothiazol-2-ylcarbamoyl}methyl)piperidine-1-carboxylic acid tert-butyl ester, 2 ml of dioxane and 2 ml of 4N hydrochloric acid in dioxane is stirred for 3 hours at room temperature. The precipitate obtained is filtered off and washed with dioxane and ethyl ether to give 110 mg of 4-(2-isopropylaminoethylamino)benzenesulfonic acid 2-(2-piperid-4-ylacetylamino)benzothiazol-6-yl ester hydrochloride (white powder) in a yield of 88%.

Workup

  1. customThe precipitate obtained
  2. filtrationis filtered off
  3. washwashed with dioxane and ethyl ether

Sources & evidence

ORD record
ord-2ce6c693a3844ce0bf37386553f0b122
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

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