Hydrochloric Acid → HCID 86612150, compound

HRID 1867972Notes

Reaction equation

HRID 1867972 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15](=[O:41])[NH:16][C:17]2[S:18][C:19]3[CH:25]=[C:24]([O:26][S:27]([C:30]4[CH:35]=[CH:34][C:33]([NH:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[CH:32][CH:31]=4)(=[O:29])=[O:28])[CH:23]=[CH:22][C:20]=3[N:21]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:42]>O1CCOCC1>[ClH:42].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][C:15]([NH:16][C:17]2[S:18][C:19]3[CH:25]=[C:24]([O:26][S:27]([C:30]4[CH:31]=[CH:32][C:33]([NH:36][CH2:37][CH:38]([CH3:40])[CH3:39])=[CH:34][CH:35]=4)(=[O:29])=[O:28])[CH:23]=[CH:22][C:20]=3[N:21]=2)=[O:41])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 86612149HCID 86612149, compound

Product 1

HCID 86612150HCID 86612150, compoundYield 64%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent2×

Procedure

2nd step: A solution of 4-{[6-(4-isobutylaminobenzenesulfonyloxy)benzo-thiazol-2-ylcarbamoyl]methyl}piperidine-1-carboxylic acid tert-butyl ester (110 mg, 182 μmol), dioxane (2 ml) and 4N hydrochloric acid in dioxane is stirred for 2 hours at room temperature. The reaction medium is concentrated to dryness and the residue obtained is washed with ethyl ether to give 183 mg of 4-isobutylaminobenzenesulfonic acid 2-(2-piperid-4-ylacetylamino)benzo-thiazol-6-yl ester hydrochloride (white powder) in a yield of 64%.

Workup

  1. concentrationThe reaction medium is concentrated to dryness
  2. customthe residue obtained
  3. washis washed with ethyl ether

Sources & evidence

ORD record
ord-08ccf6e3cc1a4224a8faf9cb2b8a416c
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

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