HRID1867979

反应详情

EQUATION

反应方程式

REACTANTS

反应物

结构：CC(C)N(CCNc1ccc(S(=O)(=O)Oc2ccc3nc(NC(=O)C4CN(C(=O)OC(C)(C)C)C4)sc3c2)cc1)C(C)C

HCID57980857

未命名化合物

2 次

PRODUCTS

生成物

结构：CC(C)N(CCNc1ccc(S(=O)(=O)Oc2ccc3nc(NC(=O)CCCCCCCN)sc3c2)cc1)C(C)C

HCID11577904

未命名化合物

收率 212.8%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID31275

1,4-Dioxane

C4H8O2

2 次

PROCEDURE

实验过程

3 ml of hydrochloric dioxane are added to a solution of 153 mg of 3-{6-[4-(2-diisopropylaminoethylamino)benzenesulfonyloxy]benzothiazol-2-yl-carbamoyl}azetidine-1-carboxylic acid tert-butyl ester (intermediate 36) in 3 ml of dioxane. The resulting solution is stirred for 5 hours at room temperature and then evaporated under reduced pressure to give 152 mg of 4-(2-diisopropylaminoethylamino)benzenesulfonic acid 2-(8-aminooctanoylamino)-benzothiazol-6-yl ester.

WORKUP

后处理

customevaporated under reduced pressure

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-6555cfee2db44cbf8671b1a7be813451
来源数据集: uspto-grants-2009_12
DOI: 10.6084/m9.figshare.5104873.v1
专利: US07632952B2
来源说明: uspto-grants-2009_12

反应 SMILES

C(OC(N1[CH2:11][CH:10]([C:12](=[O:43])[NH:13][C:14]2[S:15][C:16]3[CH:22]=[C:21]([O:23][S:24]([C:27]4[CH:32]=[CH:31][C:30]([NH:33][CH2:34][CH2:35][N:36]([CH:40]([CH3:42])[CH3:41])[CH:37]([CH3:39])[CH3:38])=[CH:29][CH:28]=4)(=[O:26])=[O:25])[CH:20]=[CH:19][C:17]=3[N:18]=2)C1)=O)(C)(C)C>O1CCOCC1>[NH2:18][CH2:17][CH2:16][CH2:22][CH2:21][CH2:20][CH2:11][CH2:10][C:12]([NH:13][C:14]1[S:15][C:16]2[CH:22]=[C:21]([O:23][S:24]([C:27]3[CH:28]=[CH:29][C:30]([NH:33][CH2:34][CH2:35][N:36]([CH:37]([CH3:38])[CH3:39])[CH:40]([CH3:42])[CH3:41])=[CH:31][CH:32]=3)(=[O:26])=[O:25])[CH:20]=[CH:19][C:17]=2[N:18]=1)=[O:43]