HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-{6-[4-(2-Diisopropylaminoethylamino)benzenesulfonyloxy]benzothiazol-2-yl-carbamoyl}azetidine-1-carboxylic acid tert-butyl ester → 4-(2-Diisopropylaminoethylamino)benzenesulfonic acid 2-(8-aminooctanoylamino)-benzothiazol-6-yl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-{6-[4-(2-Diisopropylaminoethylamino)benzenesulfonyloxy]benzothiazol-2-yl-carbamoyl}azetidine-1-carboxylic acid tert-butyl ester | HCID 57980857 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-(2-Diisopropylaminoethylamino)benzenesulfonic acid 2-(8-aminooctanoylamino)-benzothiazol-6-yl ester | HCID 11577904 | 212.8% |
Reaction Steps
3 ml of hydrochloric dioxane are added to a solution of 153 mg of 3-{6-[4-(2-diisopropylaminoethylamino)benzenesulfonyloxy]benzothiazol-2-yl-carbamoyl}azetidine-1-carboxylic acid tert-butyl ester (intermediate 36) in 3 ml of dioxane. The resulting solution is stirred for 5 hours at room temperature and then evaporated under reduced pressure to give 152 mg of 4-(2-diisopropylaminoethylamino)benzenesulfonic acid 2-(8-aminooctanoylamino)-benzothiazol-6-yl ester.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632952B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-6555cfee2db44cbf8671b1a7be813451 |
| Source note | uspto-grants-2009_12 |