Propionic Acid → 4-Fluorobenzenesulfonic acid 2-propionyl-aminobenzothiazol-6-yl ester

HRID 1867985Notes

Reaction equation

HRID 1867985 reaction equation
C(N[C:6]1[S:7][C:8]2[CH:14]=[C:13]([O:15][S:16]([C:19]3[CH:24]=[CH:23][C:22]([F:25])=[CH:21][CH:20]=3)(=[O:18])=[O:17])[CH:12]=[CH:11][C:9]=2[N:10]=1)(=O)CC.[NH2:26]C1SC2C=C(OS(C3C=CC(F)=CC=3)(=O)=O)C=CC=2N=1.[C:47]([OH:51])(=O)[CH2:48][CH3:49]>>[C:47]([C:6]1[S:7][C:8]2[CH:14]=[C:13]([O:15][S:16]([C:19]3[CH:20]=[CH:21][C:22]([F:25])=[CH:23][CH:24]=3)(=[O:17])=[O:18])[CH:12]=[C:11]([NH2:26])[C:9]=2[N:10]=1)(=[O:51])[CH2:48][CH3:49]

Participants

4

Reactant 3

HCID 1032Propionic AcidHCID 579808144-Fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester2×HCID 579808244-Fluorobenzenesulfonic acid 2-propionylaminobenzothiazol-6-yl ester

Product 1

HCID 867610314-Fluorobenzenesulfonic acid 2-propionyl-aminobenzothiazol-6-yl esterYield 93%

Procedure

According to the method of intermediate 46, 4-fluorobenzenesulfonic acid 2-propionylaminobenzothiazol-6-yl ester is prepared via the action of 4-fluorobenzenesulfonic acid 2-aminobenzothiazol-6-yl ester (intermediate 16, brevetbenzothiazole_V2) with propionic acid. The product, 0.397 g, is obtained in a yield of 93%.

Workup

  1. customThe product, 0.397 g, is obtained in a yield of 93%

Sources & evidence

ORD record
ord-9b93de5158494600bc2bd829b7169940
Source dataset
uspto-grants-2009_12
Patent number
US07632952B2

Reaction notes

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