Hydrochloric Acid → 4-(3,4-Dichloro-benzenesulfonyl)-piperidine

関与物質

役割	名称	HCID	仕込み量
反応物	Hydrochloric Acid	HCID 313	—
反応物	Sodium Carbonate	HCID 10340	—
反応物	Tert-butyl 4-[(3,4-dichlorophenyl)sulfonyl]piperidine-1-carboxylate	HCID 68550800	—
溶媒	Methanol	HCID 887	—
生成物	4-(3,4-Dichloro-benzenesulfonyl)-piperidine	HCID 22397499	79.3%

反応手順

A mixture of the sulfone from Step 7C (3.09 g, 7.8 mmol), MeOH (21 mL), and 5N HCl (4.5 mL) was heated to reflux for 1.5 h. The mixture was cooled to room temperature and sat. Na2CO3 solution (80 mL) was added. The mixture was extracted with CH2Cl2 (2×100 mL). The organic phase washed with H2O and brine, dried (MgSO4) and concentrated to afford the amine (1.82 g), a white foam, in 79% yield.

情報源と証拠

DOI	10.6084/m9.figshare.5104873.v1
特許番号	US07632838B2
出典データセット	uspto-grants-2009_12
ORD ID	ord-432e23b2e5314003886ac50bc41be741
出典メモ	uspto-grants-2009_12