反应详情

A mixture of the sulfone from Step 7C (3.09 g, 7.8 mmol), MeOH (21 mL), and 5N HCl (4.5 mL) was heated to reflux for 1.5 h. The mixture was cooled to room temperature and sat. Na2CO3 solution (80 mL) was added. The mixture was extracted with CH2Cl2 (2×100 mL). The organic phase washed with H2O and brine, dried (MgSO4) and concentrated to afford the amine (1.82 g), a white foam, in 79% yield.

1. temperaturewas heated
2. temperatureto reflux for 1.5 h
3. extractionThe mixture was extracted with CH2Cl2 (2×100 mL)
4. washThe organic phase washed with H2O and brine
5. dry with materialdried (MgSO4)
6. concentrationconcentrated