HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline, 1-chloro- → 1-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline, 1-chloro- | HCID 140539 | — |
| Reactant | 4-(3,4-Dichloro-benzenesulfonyl)-piperidine | HCID 22397499 | — |
| Product | 1-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}isoquinoline | HCID 68548032 | 100.1% |
Reaction Steps
Using the procedure from Example 7A, Step 7E, 4-[(3,4-dichlorophenyl)sulfonyl]piperidine (Example 1, Step 4, 150 mg, 0.51 mmol) was reacted with 1-chloroisoquinoline (100 mg, 0.61 mmol) to afford the title compound (215 mg), a white solid, in 51% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-eefe84f6b50649c8a30750b1ff6e788e |
| Source note | uspto-grants-2009_12 |