Isoquinoline, 1-chloro- → 1-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}isoquinoline

HRID 1868036Notes

Reaction equation

HRID 1868036 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].Cl[C:19]1[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH:22]=[CH:21][N:20]=1>>[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([CH:12]2[CH2:17][CH2:16][N:15]([C:19]3[C:28]4[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=4)[CH:22]=[CH:21][N:20]=3)[CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 2

HCID 140539Isoquinoline, 1-chloro-HCID 223974994-(3,4-Dichloro-benzenesulfonyl)-piperidine

Product 1

HCID 685480321-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}isoquinolineYield 100.1%

Procedure

Using the procedure from Example 7A, Step 7E, 4-[(3,4-dichlorophenyl)sulfonyl]piperidine (Example 1, Step 4, 150 mg, 0.51 mmol) was reacted with 1-chloroisoquinoline (100 mg, 0.61 mmol) to afford the title compound (215 mg), a white solid, in 51% yield.

Sources & evidence

ORD record
ord-eefe84f6b50649c8a30750b1ff6e788e
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…