HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloronicotinonitrile → 2-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}nicotinonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloronicotinonitrile | HCID 81079 | — |
| Reactant | 4-(3,4-Dichloro-benzenesulfonyl)-piperidine | HCID 22397499 | — |
| Product | 2-{4-[(3,4-Dichlorophenyl)sulfonyl]piperidin-1-yl}nicotinonitrile | HCID 68550871 | 99.9% |
Reaction Steps
Using the procedure from Example 7A, Step 7E, 4-[(3,4-dichlorophenyl)sulfonyl]piperidine (150 mg, 0.51 mmol) was reacted with 2-chloro-3-cyanopyridine (85 mg, 0.61 mmol) to afford the title compound (202 mg), a white solid, in 77% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-8cdfe231bc044f2a8d1d95e5067f9c72 |
| Source note | uspto-grants-2009_12 |