3,4,5-Trichloropyridine → 3,5-Dichloro-4-{4-[(3,4-dichlorophenyl)sulfonyl]piperidin-1-yl}pyridine

HRID 1868038Notes

Reaction equation

HRID 1868038 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:9]([CH:12]2[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]2)(=[O:11])=[O:10])[CH:5]=[CH:6][C:7]=1[Cl:8].[Cl:18][C:19]1[CH:20]=[N:21][CH:22]=[C:23]([Cl:26])[C:24]=1Cl>>[Cl:18][C:19]1[CH:20]=[N:21][CH:22]=[C:23]([Cl:26])[C:24]=1[N:15]1[CH2:16][CH2:17][CH:12]([S:9]([C:4]2[CH:5]=[CH:6][C:7]([Cl:8])=[C:2]([Cl:1])[CH:3]=2)(=[O:11])=[O:10])[CH2:13][CH2:14]1

Participants

3

Reactant 2

HCID 37865313,4,5-TrichloropyridineHCID 223974994-(3,4-Dichloro-benzenesulfonyl)-piperidine

Product 1

HCID 685509943,5-Dichloro-4-{4-[(3,4-dichlorophenyl)sulfonyl]piperidin-1-yl}pyridineYield 55%

Procedure

Using the procedure from Example 7A, Step 7E, 4-[(3,4-dichlorophenyl)sulfonyl]piperidine (150 mg, 0.51 mmol) was reacted with 3,4,5-trichloropyridine (224 mg, 1.22 mmol) to afford the title compound (66 mg), a white solid, in 55% yield.

Sources & evidence

ORD record
ord-c5eccfd203f24a18baec73a3079b8edb
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…