HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isoquinoline, 1-chloro- → 1-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinoline
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isoquinoline, 1-chloro- | HCID 140539 | — |
| Reactant | 4-(2-Naphthylsulfonyl)piperidine | HCID 22721937 | — |
| Product | 1-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinoline | HCID 68554196 | 73.6% |
Reaction Steps
Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (130 mg, 0.51 mmol) was reacted with 1-chloroisoquinoline (164 mg, 1.0 mmol) to afford the title compound (151 mg), a white solid, in 31% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-c739d2f1c98d4db3b3a8507e4ce9f083 |
| Source note | uspto-grants-2009_12 |