Isoquinoline, 1-chloro- → 1-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinoline

HRID 1868045Notes

Reaction equation

HRID 1868045 reaction equation
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]1)(=[O:13])=[O:12].Cl[C:21]1[C:30]2[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:24]=[CH:23][N:22]=1>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[S:11]([CH:14]1[CH2:19][CH2:18][N:17]([C:21]2[C:30]3[C:25](=[CH:26][CH:27]=[CH:28][CH:29]=3)[CH:24]=[CH:23][N:22]=2)[CH2:16][CH2:15]1)(=[O:12])=[O:13]

Participants

3

Reactant 2

HCID 140539Isoquinoline, 1-chloro-HCID 227219374-(2-Naphthylsulfonyl)piperidine

Product 1

HCID 685541961-[4-(2-Naphthylsulfonyl)piperidin-1-yl]isoquinolineYield 73.6%

Procedure

Using the procedure from Example 7A, Step 7E, 4-(2-naphthylsulfonyl)piperidine (130 mg, 0.51 mmol) was reacted with 1-chloroisoquinoline (164 mg, 1.0 mmol) to afford the title compound (151 mg), a white solid, in 31% yield.

Sources & evidence

ORD record
ord-c739d2f1c98d4db3b3a8507e4ce9f083
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…