2,3-Dichloropyridine → HCID 68552401, compound

HRID 1868053Notes

Reaction equation

HRID 1868053 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([S:8]([CH:11]2[CH2:16][CH2:15][NH:14][CH2:13][CH2:12]2)(=[O:10])=[O:9])[CH:5]=[CH:6][CH:7]=1.Cl[C:18]1[C:23]([Cl:24])=[CH:22][CH:21]=[CH:20][N:19]=1.CCN(C(C)C)C(C)C>O1CCOCC1>[Cl:24][C:23]1[C:18]([N:14]2[CH2:15][CH2:16][CH:11]([S:8]([C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)(=[O:10])=[O:9])[CH2:12][CH2:13]2)=[N:19][CH:20]=[CH:21][CH:22]=1

Participants

5

Reactant 3

HCID 169882,3-DichloropyridineHCID 81531DiisopropylethylamineHCID 534176984-[(3-Chlorophenyl)sulfonyl]piperidine

Product 1

HCID 68552401HCID 68552401, compoundYield 34.4%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

Using the procedure from Example 7A, 4-[(3-chlorophenyl)sulfonyl]piperidine (150 mg, 0.58 mmol) was reacted with 2,3-dichloropyridine (173 mg, 1.16 mmol), DIEA (0.3 ml, 1.74) and 1,4-dioxane (0.2 ml) to afford the title compound (74 mg), a beige solid, in 34% yield.

Sources & evidence

ORD record
ord-d4211b2f0a87446fbc55fbded38fd45a
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…