HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Chloro-3-nitropyridine → 2-{4-[(3-Chlorophenyl)sulfonyl]piperidin-1-yl}-3-nitropyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Chloro-3-nitropyridine | HCID 79613 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-[(3-Chlorophenyl)sulfonyl]piperidine | HCID 53417698 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 2-{4-[(3-Chlorophenyl)sulfonyl]piperidin-1-yl}-3-nitropyridine | HCID 68555464 | 81.3% |
Reaction Steps
Using the procedure from Example 7A, 4-[(3-chlorophenyl)sulfonyl]piperidine (100 mg, 0.38 mmol) was reacted with 2-chloro-3-nitropyridine (122 mg, 0.76 mmol), DIEA (0.2 ml, 1.14) and 1,4-dioxane (0.3 ml) to afford the title compound (118 mg), a yellow solid, in 81% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07632838B2 |
| Source dataset | uspto-grants-2009_12 |
| ORD ID | ord-31a7bdf152bf435f8e98832fcf22e98d |
| Source note | uspto-grants-2009_12 |