Benzene, 1-bromo-2-(trifluoromethyl)- → HCID 68546896, compound

HRID 1868074Notes

Reaction equation

HRID 1868074 reaction equation
[C:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11]([CH:14]2[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]2)(=[O:13])=[O:12])=[CH:7][CH:6]=1)([CH3:4])([CH3:3])[CH3:2].Br[C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=1[C:27]([F:30])([F:29])[F:28]>>[C:1]([C:5]1[CH:6]=[CH:7][C:8]([S:11]([CH:14]2[CH2:15][CH2:16][N:17]([C:21]3[CH:26]=[CH:25][CH:24]=[CH:23][C:22]=3[C:27]([F:30])([F:29])[F:28])[CH2:18][CH2:19]2)(=[O:13])=[O:12])=[CH:9][CH:10]=1)([CH3:4])([CH3:2])[CH3:3]

Participants

3

Reactant 2

HCID 9806Benzene, 1-bromo-2-(trifluoromethyl)-HCID 185386364-[(4-Tert-butylphenyl)sulfonyl]piperidine

Product 1

HCID 68546896HCID 68546896, compoundYield 17%

Procedure

Using the procedure from Example 7A, 4-[(4-tert-butylphenyl)sulfonyl]piperidine (100 mg, 0.36 mmol) was reacted with 2-bromobenzotrifluoride (59 μl, 0.43 mmol) to afford the title compound (26 mg), a white solid, in 17% yield.

Sources & evidence

ORD record
ord-4d337188950d42fca644f6cff6112c99
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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