Trifluoroacetic acid → Trifluoroacetic acid

HRID 1868084Notes

Reaction equation

HRID 1868084 reaction equation
[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[O:4][CH:5]1[CH2:10][CH2:9][N:8](C(OC(C)(C)C)=O)[CH2:7][CH2:6]1.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]>C(Cl)Cl>[Cl:1][C:2]1[CH:21]=[CH:20][CH:19]=[C:18]([Cl:22])[C:3]=1[O:4][CH:5]1[CH2:6][CH2:7][NH:8][CH2:9][CH2:10]1.[C:23]([OH:29])([C:25]([F:28])([F:27])[F:26])=[O:24]

Participants

5

Reactant 2

HCID 6422Trifluoroacetic acidHCID 59177677HCID 59177677, compound

Product 2

HCID 6422Trifluoroacetic acidHCID 28918779HCID 28918779, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

tert-Butyl 4-(2,6-dichlorophenoxy)piperidine-1-carboxylate (5.54 g) was mixed with 50 ml of mixture of TFA and CH2Cl2 (1:1). The mixture was stirred at room temperature for 4 hours. The solvents were removed under vacuum residue was Freeze-dried using CH3CN/water system. The desired 4-(2,6-dichlorophenoxy)piperidine was obtained as TFA salt (white solid) in 100% yield.

Workup

  1. customThe solvents were removed under vacuum residue
  2. customwas Freeze-dried

Sources & evidence

ORD record
ord-40fee2b32094409287a5025f92d3694c
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

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