m-Bromobenzenesulphonyl chloride → HCID 68556406, compound

HRID 1868151Notes

Reaction equation

HRID 1868151 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][C:5]([C@H:8]2[CH2:13][CH2:12][NH:11][C@@H:10]([CH3:14])[CH2:9]2)=[C:4]([C:15]([F:18])([F:17])[F:16])[CH:3]=1.[Br:19][C:20]1[CH:21]=[C:22]([S:26](Cl)(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1>>[Br:19][C:20]1[CH:21]=[C:22]([S:26]([N:11]2[CH2:12][CH2:13][C@H:8]([C:5]3[CH:6]=[CH:7][C:2]([F:1])=[CH:3][C:4]=3[C:15]([F:18])([F:16])[F:17])[CH2:9][C@@H:10]2[CH3:14])(=[O:28])=[O:27])[CH:23]=[CH:24][CH:25]=1

Participants

3

Reactant 2

HCID 17943m-Bromobenzenesulphonyl chlorideHCID 68553926HCID 68553926, compound

Product 1

HCID 68556406HCID 68556406, compoundYield 97%

Procedure

Prepared from (2S,4S)-4-(4-fluoro-2-(trifluoromethyl)phenyl)-2-methylpiperidine (120 mg, 0.46 mmol) and 3-bromophenylsulfonyl chloride (99.4 mL, 0.69 mmol) according to scheme III-11 in 97% yield. HRMS: calcd for C19H18BrF4NO2S+H+, 480.02505. found (ESI-FTMS, [M+H]1+), 480.02396.

Sources & evidence

ORD record
ord-9674f96895fe401fbaf637e8075ebbc4
Source dataset
uspto-grants-2009_12
Patent number
US07632838B2

Reaction notes

Loading…