HCID 57983265, compound → HCID 57983254, compound

HRID 1868366Notes

Reaction equation

HRID 1868366 reaction equation
C1(C[N:8]([CH2:16][C@@H:17]2[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:19][C@H:18]2[OH:27])CC2C=CC=CC=2)C=CC=CC=1.[H][H]>CO.[Pd]>[NH2:8][CH2:16][C@@H:17]1[CH2:22][CH2:21][N:20]([CH2:23][CH2:24][CH2:25][CH3:26])[CH2:19][C@H:18]1[OH:27]

Participants

5

Reactant 2

HCID 57983265HCID 57983265, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 57983254HCID 57983254, compoundYield 93.8%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 887MethanolSolvent

Procedure

A mixture of intermediate (29) (0.079 mol) in methanol (250 ml) was hydrogenated with palladium-on-carbon (10%) (2 g) as a catalyst. After uptake of hydrogen (2 equivalents), the catalyst was filtered over celite and the filtrate was evaporated, yielding 13.8 g of (trans)-4-(aminomethyl)-1-butyl-3-piperidinol (intermediate 30).

Workup

  1. customthe filtrate was evaporated

Sources & evidence

ORD record
ord-f33806b999b2425186afce990cc364d4
Source dataset
uspto-grants-2009_12
Patent number
US07635706B2

Reaction notes

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