Cyclobutylamine → HCID 9978590, compound

HRID 1868377Notes

Reaction equation

HRID 1868377 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([Cl:8])=[CH:4][C:3]=1[NH:9][C:10]1[N:15]=[C:14]([C:16]([F:19])([F:18])[F:17])[C:13]([C:20]([OH:22])=O)=[CH:12][N:11]=1.[CH:23]1([NH2:27])[CH2:26][CH2:25][CH2:24]1>>[CH:23]1([NH:27][C:20]([C:13]2[C:14]([C:16]([F:19])([F:18])[F:17])=[N:15][C:10]([NH:9][C:3]3[CH:4]=[C:5]([Cl:8])[CH:6]=[CH:7][C:2]=3[Cl:1])=[N:11][CH:12]=2)=[O:22])[CH2:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 75645CyclobutylamineHCID 16719435HCID 16719435, compound

Product 1

HCID 9978590HCID 9978590, compound

Procedure

In a manner similar to Reference Example 1(c) 2-(2,5-dichlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (50 mg) and cyclobutylamine (19 μl)-afforded the title compound (56 mg).

Sources & evidence

ORD record
ord-b047f39df7964effa767f2d2f52544cc
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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