HCID 2781528, compound → HCID 10480877, compound

HRID 1868382Notes

Reaction equation

HRID 1868382 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14](Cl)=[N:15][CH:16]=2)=[O:10])[CH2:3][CH2:2]1.[CH3:22][S:23][C:24]1[C:30]([C:31]([F:34])([F:33])[F:32])=[CH:29][CH:28]=[CH:27][C:25]=1[NH2:26]>C(#N)C>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14]([NH:26][C:25]3[CH:27]=[CH:28][CH:29]=[C:30]([C:31]([F:32])([F:33])[F:34])[C:24]=3[S:23][CH3:22])=[N:15][CH:16]=2)=[O:10])[CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 2781528HCID 2781528, compoundHCID 57982687HCID 57982687, compound

Product 1

HCID 10480877HCID 10480877, compoundYield 14.4%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

2-Chloro-4-trifluoromethyl-pyrimidin-5-carboxylic acid (tetrahydropyran-4-ylmethyl)-amide (50 mg), 2-methylthio-3-(trifluoromethyl)aniline (125 mg, ex Maybridge) and acetonitrile (0.5 ml) were heated at 190° under microwave irradiation for 30 minutes. The solvent was evaporated in vacuo and the residue purified by mass-directed autopreparation technique, to give the title compound (11 mg).

Workup

  1. customThe solvent was evaporated in vacuo
  2. customthe residue purified by mass-directed autopreparation technique

Sources & evidence

ORD record
ord-f1d818141fbe431d9e1d16854cb98991
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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