Cyclopropylamine → 2-(3-Chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopropylamide

HRID 1868385Notes

Reaction equation

HRID 1868385 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([NH:8][C:9]2[N:14]=[C:13]([C:15]([F:18])([F:17])[F:16])[C:12]([C:19](O)=[O:20])=[CH:11][N:10]=2)[CH:5]=[CH:6][CH:7]=1.[CH:22]1([NH2:25])[CH2:24][CH2:23]1>>[CH:22]1([NH:25][C:19]([C:12]2[C:13]([C:15]([F:18])([F:17])[F:16])=[N:14][C:9]([NH:8][C:4]3[CH:5]=[CH:6][CH:7]=[C:2]([Cl:1])[CH:3]=3)=[N:10][CH:11]=2)=[O:20])[CH2:24][CH2:23]1

Participants

3

Reactant 2

HCID 69828CyclopropylamineHCID 167196552-(3-Chlorophenylamino)-4-trifluoromethylpyrimidine-5-carboxylic acid

Product 1

HCID 104060122-(3-Chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclopropylamideYield 81.4%

Procedure

In a manner similar to Reference Example 1 (c) 2-(3-chlorophenylamino)-4-trifluoromethyl-pyrimidine-5-carboxylic acid (35 mg) and cyclopropylamine (9 mg, ex Lancaster) afforded the title compound (32 mg).

Sources & evidence

ORD record
ord-2b56ecdc407d49529b251dedd39dafbe
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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