Hydrochloric Acid → Methyl((oxan-4-yl)methyl)amine hydrochloride

HRID 1868387Notes

Reaction equation

HRID 1868387 reaction equation
C(O[C:6](=O)[N:7](C)[CH2:8][CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1)(C)(C)C.[ClH:17]>O1CCOCC1>[ClH:17].[CH3:6][NH:7][CH2:8][CH:9]1[CH2:14][CH2:13][O:12][CH2:11][CH2:10]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 57982626HCID 57982626, compound

Product 1

HCID 22737007Methyl((oxan-4-yl)methyl)amine hydrochloride

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

A solution of N-methyl-N-(tetrahydro-pyran-4-ylmethyl)-carbamic acid tert-butyl ester (740 mg) in 4N hydrochloric acid in 1,4-dioxan (10 ml, ex Aldrich) was stirred at room temperature for 1 h. The dioxan was removed under reduced pressure and the residue triturated with ether. The solid was filtered onto a sinter, washed with ether and dried, to afford N-methyl-N-(tetrahydro-pyran-4-ylmethyl)-amine hydrochloride (460 mg).

Workup

  1. customThe dioxan was removed under reduced pressure
  2. customthe residue triturated with ether
  3. filtrationThe solid was filtered onto a sinter
  4. washwashed with ether
  5. customdried

Sources & evidence

ORD record
ord-13c521263bec42b8bdb2804d08be11b8
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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