4-Chloro-3-methoxyaniline → HCID 57982667, compound

HRID 1868394Notes

Reaction equation

HRID 1868394 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14](Cl)=[N:15][CH:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:22][C:23]1[CH:28]=[CH:27][C:26]([NH2:29])=[CH:25][C:24]=1[O:30][CH3:31]>O1CCOCC1>[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14]([NH:29][C:26]3[CH:27]=[CH:28][C:23]([Cl:22])=[C:24]([O:30][CH3:31])[CH:25]=3)=[N:15][CH:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 131036924-Chloro-3-methoxyanilineHCID 579825812-Chloro-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide

Product 1

HCID 57982667HCID 57982667, compoundYield 47.9%

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

In a manner similar to Example 243, 2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide (Example 166a) (50 mg) in 1,4-dioxan (1 ml) and 4-chloro-3-methoxy-phenylamine (Wychem) (122 mg) were reacted to give the title compound (33 mg)

Sources & evidence

ORD record
ord-89aee481e87b44c6bfd85b4953a8ccb3
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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