5-Chloro-2-methylaniline → HCID 57982619, compound

HRID 1868395Notes

Reaction equation

HRID 1868395 reaction equation
[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14](Cl)=[N:15][CH:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.[Cl:22][C:23]1[CH:24]=[CH:25][C:26]([CH3:30])=[C:27]([CH:29]=1)[NH2:28]>>[CH:1]1([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14]([NH:28][C:27]3[CH:29]=[C:23]([Cl:22])[CH:24]=[CH:25][C:26]=3[CH3:30])=[N:15][CH:16]=2)=[O:10])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 72605-Chloro-2-methylanilineHCID 579825812-Chloro-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide

Product 1

HCID 57982619HCID 57982619, compoundYield 54.3%

Procedure

In a manner similar to Example 243, 2-chloro-4-trifluoromethyl-pyrimidine-5-carboxylic acid cyclohexylmethyl-amide (Example 166a) (50 mg) in 1,4-ioxan (1 ml) and 5-chloro-2-methyl aniline (Aldrich) (110 mg) were reacted to give the title compound (36 mg)

Sources & evidence

ORD record
ord-344d373d4a1949f599710a57c031209f
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

Loading…