4-Bromo-2-(trifluoromethyl)aniline → HCID 57982610, compound

HRID 1868400Notes

Reaction equation

HRID 1868400 reaction equation
[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14](Cl)=[N:15][CH:16]=2)=[O:10])[CH2:3][CH2:2]1.[F:22][C:23]([F:33])([F:32])[C:24]1[CH:30]=[C:29]([Br:31])[CH:28]=[CH:27][C:25]=1[NH2:26]>>[O:1]1[CH2:6][CH2:5][CH:4]([CH2:7][NH:8][C:9]([C:11]2[C:12]([C:18]([F:21])([F:20])[F:19])=[N:13][C:14]([NH:26][C:25]3[CH:27]=[CH:28][C:29]([Br:31])=[CH:30][C:24]=3[C:23]([F:33])([F:22])[F:32])=[N:15][CH:16]=2)=[O:10])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 679604-Bromo-2-(trifluoromethyl)anilineHCID 57982687HCID 57982687, compound

Product 1

HCID 57982610HCID 57982610, compound

Procedure

2-Chloro-4-trifluoromethyl-pyrimidin-5-carboxylic acid (tetrahydro-pyran-4-ylmethyl)-amide (80 mg) in 2-trifluoromethyl-4-bromoaniline (0.5 ml) was heated at 190° C. under microwave irradiation for 20 minutes. The sample was purified by mass directed auto-purification to afford the title compound (21 mg).

Workup

  1. customThe sample was purified by mass
  2. customauto-purification

Sources & evidence

ORD record
ord-fb4c46170eb94b93bb3b7d9fc85eff07
Source dataset
uspto-grants-2009_12
Patent number
US07635701B2

Reaction notes

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