Aluminium lithium hydride → 2,4,6-trimethyl-N-(2,2,2-trifluoro-1-hydroxymethylethyl)benzenesulfonamide

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Reaction Steps

To a solution of 1.0 g (2.8 mmol) of 3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propionic acid ethyl ester in 10 mL of THF was added 255 mg (6.5 mmol) of lithium aluminum hydride. The mixture stirred for 1 hour and was then cautiously quenched with water dropwise. Magnesium sulfate was then added and the mixture was filtered through CELITE® filter aid to afford 690 mg (78%) of 2,4,6-trimethyl-N-(2,2,2-trifluoro-1-hydroxymethylethyl)benzenesulfonamide.

Provenance & Evidence