反应详情

To a solution of 1.0 g (2.8 mmol) of 3,3,3-trifluoro-2-(2,4,6-trimethylbenzenesulfonylamino)propionic acid ethyl ester in 10 mL of THF was added 255 mg (6.5 mmol) of lithium aluminum hydride. The mixture stirred for 1 hour and was then cautiously quenched with water dropwise. Magnesium sulfate was then added and the mixture was filtered through CELITE® filter aid to afford 690 mg (78%) of 2,4,6-trimethyl-N-(2,2,2-trifluoro-1-hydroxymethylethyl)benzenesulfonamide.

1. customwas then cautiously quenched with water dropwise
2. additionMagnesium sulfate was then added
3. filtrationthe mixture was filtered through CELITE®
4. filtrationfilter aid