Tert-butyl {[1-(1-ethylcyclobutyl)prop-2-ynyl]oxy}dimethylsilane → 4-{[Tert-butyl(dimethyl)silyl]oxy}-4-(1-ethylcyclobutyl)butanal

HRID 1868440Notes

Reaction equation

HRID 1868440 reaction equation
[CH2:1]([C:5]1([CH:9]([O:14][Si:15]([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16])[CH2:10][CH2:11][CH:12]=[O:13])[CH2:8][CH2:7][CH2:6]1)[CH2:2]CC.C([Si](OC(C1(CC)CCC1)C#C)(C)C)(C)(C)C>CCOC(C)=O.CCCCCC>[Si:15]([O:14][CH:9]([C:5]1([CH2:1][CH3:2])[CH2:8][CH2:7][CH2:6]1)[CH2:10][CH2:11][CH:12]=[O:13])([C:18]([CH3:21])([CH3:20])[CH3:19])([CH3:17])[CH3:16]

Participants

4

Reactant 2

HCID 85825701Tert-butyl {[1-(1-ethylcyclobutyl)prop-2-ynyl]oxy}dimethylsilaneHCID 866001634-(1-Butylcyclobutyl) 4-{[tert-butyl(dimethyl)silyl]oxy}butanal

Product 1

HCID 866001624-{[Tert-butyl(dimethyl)silyl]oxy}-4-(1-ethylcyclobutyl)butanal

Reagents, catalysts & solvents 1

HCID 21226206Ethyl acetate hexaneSolvent

Procedure

The title compound was prepared according to the procedure described for intermediate 2.6 from tert-butyl {[1-(1-ethylcyclobutyl)prop-2-ynyl]oxy}dimethylsilane. (intermediate 21.5). Rf 0.6 (EtOAc/hexanes 1/4).

Sources & evidence

ORD record
ord-1eadf7de9b614503a042f62510e99015
Source dataset
uspto-grants-2009_12
Patent number
US07635713B2

Reaction notes

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