Hydrazine hydrate (1:1) → HCID 178489323, compound

HRID 1868444Notes

Reaction equation

HRID 1868444 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]2[N:16]=CC=C[N:12]2[CH:17]=1.NN.O>CCO>[CH3:1][O:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][C:4]=1[C:9]1[N:10]=[C:11]([NH2:16])[NH:12][CH:17]=1

Participants

4

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 15754618HCID 15754618, compound

Product 1

HCID 178489323HCID 178489323, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Conditions

Temperature
75 °C

Procedure

To a stirred solution of 2-(2-methoxyphenyl)imidazo[1,2-α]pyrimidine (1.24 g, 5.5 mmol) in EtOH (8 mL) was added NH2NH2.H2O (0.3 mL, 6.1 mmol). After heating to 75° C. for 24 h, the reaction was concentrated under reduced pressure. The residue was suspended in Et2O and filtered to collect 4-(2-methoxyphenyl)-1H-imidazol-2-amine (1 g, 96%) as a light yellow solid.

Workup

  1. concentrationthe reaction was concentrated under reduced pressure
  2. filtrationfiltered
  3. customto collect 4-(2-methoxyphenyl)-1H-imidazol-2-amine (1 g, 96%) as a light yellow solid

Sources & evidence

ORD record
ord-41d1469e569f45fbb5abd58ffbcaa026
Source dataset
uspto-grants-2009_12
Patent number
US07635699B2

Reaction notes

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