HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1868458Generated: October 31, 2026
Trifluoroacetic acid → 5-(2,4-Dichlorophenyl)-2-(ethoxycarbonyl)-7-methylimidazo[1,2-a]pyrimidine-6-carboxylic acid
https://huagongshe.com/reaction/1868458
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | 6-Tert-butyl 2-ethyl 5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2,6-dicarboxylate | HCID 46901743 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 5-(2,4-Dichlorophenyl)-2-(ethoxycarbonyl)-7-methylimidazo[1,2-a]pyrimidine-6-carboxylic acid | HCID 46901744 | 100.3% |
Reaction Steps
To a stirred solution of 6-tert-butyl 2-ethyl 5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-2,6-dicarboxylate (1.14 g, 2.53 mmol) in CH2Cl2 (5 mL) was added TFA (5 mL). The reaction was heated to 60° C. for 30 h and concentrated under reduced pressure to obtain 5-(2,4-dichlorophenyl)-2-(ethoxycarbonyl)-7-methylimidazo[1,2-a]pyrimidine-6-carboxylic acid (1 g, 100% crude yield) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US07635699B2 |
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| Source dataset | uspto-grants-2009_12 |
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| ORD ID | ord-ef098ce7e7bb4ad581f2b333b30d5e47 |
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| Source note | uspto-grants-2009_12 |
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