反应详情

To a stirred solution of tert-butyl 2-carbamoyl-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-6-carboxylate (Example 156, Step 1, 50 mg, 0.12 mmol) in CH2Cl2 (3 mL) was added TFAA (50 mg, 0.24 mmol) and Et3N (33 μL, 0.24 mmol). After 2 h, the reaction was extracted with H2O and brine prior to drying over anhydrous MgSO4. Filtration, concentration under reduced pressure afforded tert-butyl 2-cyano-5-(2,4-dichlorophenyl)-7-methylimidazo[1,2-a]pyrimidine-6-carboxylate (50 mg, 95% pure) as a yellow oil.

1. extractionthe reaction was extracted with H2O and brine
2. dry with materialto drying over anhydrous MgSO4
3. filtrationFiltration, concentration under reduced pressure