HCID 68510438, compound → HCID 68511389, compound

HRID 1868508Notes

Reaction equation

HRID 1868508 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][N:10]([CH:15]1[CH:19]([O:20][Si](C(C)(C)C)(C)C)[CH2:18][N:17]([C:28](=[O:36])[C:29]2[CH:34]=[CH:33][C:32]([Cl:35])=[CH:31][CH:30]=2)[CH2:16]1)[C:11](=[O:14])[CH2:12][Cl:13])(C)(C)C>Cl.O1CCOCC1>[NH2:7][CH2:8][CH2:9][N:10]([CH:15]1[CH:19]([OH:20])[CH2:18][N:17]([C:28](=[O:36])[C:29]2[CH:30]=[CH:31][C:32]([Cl:35])=[CH:33][CH:34]=2)[CH2:16]1)[C:11](=[O:14])[CH2:12][Cl:13]

Participants

4

Reactant 1

HCID 68510438HCID 68510438, compound

Product 1

HCID 68511389HCID 68511389, compound

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 312751,4-DioxaneSolvent

Procedure

{2-[[4-(tert-Butyl-dimethyl-silanyloxy)-1-(4-chloro-benzoyl)-pyrrolidin-3-yl]-(2-chloro-acetyl)-amino]-ethyl}-carbamic acid tert-butyl ester (260 mg, 0.45 mmol) was dissolved in 1 mL of 4M HCl in dioxane solution. The mixture was stirred at RT for 1.5 h. After concentrating, a white solid was formed (200 mg). The LC-Mass showed two products as showed above. MS: (ESI), M/Z, 360 (M+1). Retention time: 1.31 min (FA-polar). MS: (ESI), M/Z, 474 (M+1). Retention time: 2.20 min (FA-polar).

Workup

  1. concentrationAfter concentrating
  2. customa white solid was formed (200 mg)

Sources & evidence

ORD record
ord-6afd3ad1e3024f178e6e20fc8a28a491
Source dataset
uspto-grants-2009_12
Patent number
US07635698B2

Reaction notes

Loading…