HCID 66968601, compound → HCID 66967948, compound

HRID 1868516Notes

Reaction equation

HRID 1868516 reaction equation
C(OC([N:8]1[CH2:12][CH:11]([OH:13])[CH:10]([N:14]2[CH2:19][CH2:18][N:17]([CH2:20][C:21]3[CH:26]=[CH:25][C:24]([Cl:27])=[CH:23][CH:22]=3)[CH2:16][CH2:15]2)[CH2:9]1)=O)(C)(C)C>C(O)=O>[Cl:27][C:24]1[CH:25]=[CH:26][C:21]([CH2:20][N:17]2[CH2:18][CH2:19][N:14]([CH:10]3[CH2:9][NH:8][CH2:12][CH:11]3[OH:13])[CH2:15][CH2:16]2)=[CH:22][CH:23]=1

Participants

3

Reactant 1

HCID 66968601HCID 66968601, compound

Product 1

HCID 66967948HCID 66967948, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

The desired compound was prepared from 3-[4-(4-Chloro-benzyl)-piperazin-1-yl]4-hydroxy-pyrrolidine-1-carboxylic acid tert-butyl ester in a manner similar to that described in Example 161. 1H-NMR (300 MHz, DMSO, HCl salt): δ 2.80-3.60 (m, 12 H), 4.20-4.35 (m, 4 H), 7.51 (d, 2 H), 7.66 (d, 2 H). Retention Time (LC, method: Formic acid polar): 0.68 min. MS (M+H+): 296

Workup

  1. custom0.68 min

Sources & evidence

ORD record
ord-f401e2aa31694fdfa66f319e303d7df2
Source dataset
uspto-grants-2009_12
Patent number
US07635698B2

Reaction notes

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