反应详情

温度

80 °C

A mixture of 2.40 g (0.0095 mol) of 6-(tert-butyl)-2-methyl-8H-indeno[2,1-b]thiophen-8-one and 2.6 mL (0.05 mol) of hydrazine monohydrate in 25 mL of diethylene glycol was stirred at 80° C. in 40 min and then refluxed for 1 h. The resulting mixture was cooled to r.t., treated with a solution of 2.68 g (0.035 mol) of KOH in 9.4 mL of water and subsequently refluxed for 2 h. The resulting mixture was poured in 150 mL of water, the precipitate was filtered, washed 5 times with 100 mL of water and dried. Yield 1.25 g (54%).

1. temperaturerefluxed for 1 h
2. temperatureThe resulting mixture was cooled to r.t.
3. temperaturesubsequently refluxed for 2 h
4. filtrationthe precipitate was filtered
5. washwashed 5 times with 100 mL of water
6. customdried