Dichloromethane → HCID 21957076, compound

HRID 1868562Notes

Reaction equation

HRID 1868562 reaction equation
C(OC(=O)[NH:7][CH2:8][CH2:9][C:10]1[CH:15]=[CH:14][C:13]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][N:17]=2)=[CH:12][CH:11]=1)(C)(C)C.ClCCl>FC(F)(F)C(O)=O>[N:17]1[CH:18]=[CH:19][CH:20]=[CH:21][C:16]=1[C:13]1[CH:14]=[CH:15][C:10]([CH2:9][CH2:8][NH2:7])=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 6344DichloromethaneHCID 21027861HCID 21027861, compound

Product 1

HCID 21957076HCID 21957076, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

[2-(4-Pyridin-2-yl-phenyl)-ethyl]-carbamic acid tert-butyl ester was dissolved in a 1:1 mixture of trifluroacetic acid:dichloromethane. The reaction mixture was stirred at room temperature overnight after which the product was recovered upon solvent removal. The TFA salt was used in the next step without further purification.

Workup

  1. customwas recovered upon solvent removal
  2. customThe TFA salt was used in the next step without further purification

Sources & evidence

ORD record
ord-7864c7eab79c4e5392f6e14cb14345eb
Source dataset
uspto-grants-2009_12
Patent number
US07635775B2

Reaction notes

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