反应详情

To a flask containing 1,1-dimethylethyl N-((8-fluoro-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycinate (1.5 g, 4.1 mmol) was added TFA (20 mL). The reaction was stirred under nitrogen for 1 hours and then concentrated in vacuo to afford an oil. Addition of water caused a white precipitate to form. The solid was collected by filtration, washed with water, washed with ether, and then dried in vacuo (0.68 g). MS (m/z)=308 (M+H)+. Calculated for C15H14FNO5 307.08.

1. concentrationconcentrated in vacuo
2. customto afford an oil
3. customto form
4. filtrationThe solid was collected by filtration
5. washwashed with water
6. washwashed with ether
7. customdried in vacuo (0.68 g)