Trifluoroacetic acid → N-((7-Cyano-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycine

HRID 1868723노트

반응식

HRID 1868723 반응식
[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:27])=[C:8]([C:16]([NH:18][CH2:19][C:20]([O:22]C(C)(C)C)=[O:21])=[O:17])[C:9](=[O:15])[C:10]2([CH3:14])[CH3:13])=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>O>[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([C:7]([OH:27])=[C:8]([C:16]([NH:18][CH2:19][C:20]([OH:22])=[O:21])=[O:17])[C:9](=[O:15])[C:10]2([CH3:14])[CH3:13])=[CH:5][CH:4]=1)#[N:2]

참가 물질

4

반응물 2

HCID 6422Trifluoroacetic acidHCID 670997611,1-Dimethylethyl N-((7-cyano-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-yl)carbonyl)glycinate

생성물 1

HCID 67099886N-((7-Cyano-4-hydroxy-1,1-dimethyl-2-oxo-naphthalen-3-yl)carbonyl)glycine수율 91.1%

시약·촉매·용매 1

HCID 962Water용매

실험 절차

1,1-Dimethylethyl N-((7-cyano-4-hydroxy-1,1-dimethyl-2-oxo-naphthalene-3-yl)carbonyl)glycinate (163 mg, 440 μmol) was stirred in TFA (1 mL, 13462 μmol) at room temperature for 20 minutes. Water was added. The resulting precipitate was filtered and washed with water to give the desired product as an off-white solid (126 mg). MS (m/e)=315.1 (M+H)+. Calculated for C16H14N2O5 314.09.

후처리

  1. filtrationThe resulting precipitate was filtered
  2. washwashed with water

출처 및 근거

ORD 기록
ord-21e9dbb48dac4b0d9e700d6cfd930d02
출처 데이터셋
uspto-grants-2009_12
특허 번호
US07635715B2

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