Trifluoroacetic acid → HCID 57983480, compound

HRID 1868825Notes

Reaction equation

HRID 1868825 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][CH:16]=1)[C:8]1([CH2:13][CH2:12][CH2:11][O:10][CH2:9]1)[C:7](=[O:17])[C:6]([C:18]([NH:20][CH2:21][C:22]([O:24]C(C)(C)C)=[O:23])=[O:19])=[C:5]2[OH:29].C(O)(C(F)(F)F)=O>C(Cl)Cl>[Cl:1][C:2]1[CH:3]=[C:4]2[C:14](=[CH:15][CH:16]=1)[C:8]1([CH2:13][CH2:12][CH2:11][O:10][CH2:9]1)[C:7](=[O:17])[C:6]([C:18]([NH:20][CH2:21][C:22]([OH:24])=[O:23])=[O:19])=[C:5]2[OH:29]

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 67099695HCID 67099695, compound

Product 1

HCID 57983480HCID 57983480, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

1,1-Dimethylethyl N-((6-chloro-4-hydroxy-2-oxo-5′,6′-dihydro-spiro[naphthalene-1,3′-pyran]-3-yl)carbonyl)glycinate (106 mg, 252 μmol) was mixed with TFA (6300 μL, 252 μmol) and stirred for 30 minutes. The product was co-evaporated with DCM (5×) to give the title compound. MS m/e=366.0 (M+H)+. Calculated for C17H16ClNO6 365.07.

Sources & evidence

ORD record
ord-93704a30116a4a26ad17f8a3686b5a12
Source dataset
uspto-grants-2009_12
Patent number
US07635715B2

Reaction notes

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