HCID 178451290, compound → HCID 178429097, compound

HRID 1868931Notes

Reaction equation

HRID 1868931 reaction equation
[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([O:18]C(C)(C)C)=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([C:24]#[C:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)[CH:5]=2>C(O)(C(F)(F)F)=O>[OH:1][C:2]1[C:3]([CH3:33])([CH3:32])[C:4]2[C:9]([C:10](=[O:23])[C:11]=1[C:12]([NH:14][CH2:15][C:16]([OH:18])=[O:17])=[O:13])=[CH:8][CH:7]=[C:6]([C:24]#[C:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)[CH:5]=2

Participants

3

Reactant 1

HCID 178451290HCID 178451290, compound

Product 1

HCID 178429097HCID 178429097, compound

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

Tert-butyl 2-(2-hydroxy-1,1-dimethyl-4-oxo-7-(2-phenylethynyl)-1,4-dihydronaphthalene-3-carboxamido)acetate (68 mg, 153 μmol) was dissolved and stirred in TFA (2 mL) at room temperature for 30 minutes. The reaction was concentrated, suspended in hexanes, filtered, washed with hexanes, and dried in a vacuum oven to give the title compound. MS (ESI) m/z: Calculated; 389.4: Observed; 390.0.

Workup

  1. concentrationThe reaction was concentrated
  2. filtrationfiltered
  3. washwashed with hexanes
  4. customdried in a vacuum oven

Sources & evidence

ORD record
ord-3cf3358c2a5940f3bd7ebf1b6ccacd57
Source dataset
uspto-grants-2009_12
Patent number
US07635715B2

Reaction notes

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