反应详情

680 mg of oxo-(4-trifluoromethyl-phenyl)-acetic acid ethyl ester and 2.2 g of triphenylphosphine are introduced into 8 ml of acetonitrile. 0.8 ml of carbon tetrachloride is then added and the mixture is heated at reflux for 4 hours. The reaction mixture is concentrated completely and the crude product is purified over silica gel. 3,3-Dichloro-2-(4-trifluoromethyl-phenyl)-acrylic acid ethyl ester is obtained. 1H-NMR (CDCl3) 300 MHz: 1.30 (t, 3H), 4.30 (q, 2H), 7.52 (d, 2H), 7.68 (d, 2H).

1. temperaturethe mixture is heated
2. temperatureat reflux for 4 hours
3. concentrationThe reaction mixture is concentrated completely
4. customthe crude product is purified over silica gel