Trifluoroacetic acid methylene chloride → Trifluoroacetate

HRID 1869197Notes

Reaction equation

HRID 1869197 reaction equation
[CH3:1][O:2][C:3](=[O:28])[C:4]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH2:12][C:13]1[C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:16]2[NH:15][CH:14]=1)[C:5]([O:7]C(C)(C)C)=[O:6].[C:29]([OH:35])([C:31]([F:34])([F:33])[F:32])=[O:30].C(Cl)Cl>>[CH3:1][O:2][C:3](=[O:28])[C:4]([C:22]1[CH:27]=[CH:26][CH:25]=[CH:24][CH:23]=1)([CH2:12][C:13]1[C:17]2=[N:18][CH:19]=[CH:20][CH:21]=[C:16]2[NH:15][CH:14]=1)[C:5]([OH:7])=[O:6].[F:32][C:31]([F:34])([F:33])[C:29]([O-:35])=[O:30]

Participants

4

Reactant 2

HCID 21863450Trifluoroacetic acid methylene chlorideHCID 86612764HCID 86612764, compound

Product 2

HCID 84468TrifluoroacetateHCID 86612763HCID 86612763, compound

Procedure

A RT solution of 2-[phenyl-(1H-pyrrolo[3,2-b]pyridin-3-yl-methyl)-malonic acid tert-butyl ester methyl ester (320 mg) in a mixture TFA/DCM (2/1, 9 mL) was stirred for 1.5 h, and concentrated to give 2-[Phenyl-(1H-pyrrolo[3,2-b]pyridin-3-yl-methyl)-malonic acid mono-methyl ester as a trifluoroacetate salt.

Workup

  1. concentrationconcentrated

Sources & evidence

ORD record
ord-6258c738078e48faafbc5fa3cdfe60af
Source dataset
uspto-grants-2009_12
Patent number
US07638517B2

Reaction notes

Loading…